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Annals of Pediatric Surgery
Fig. 2 | Annals of Pediatric Surgery

Fig. 2

From: Spontaneous intestinal perforation followed by necrotizing enterocolitis in an extremely low birth weight neonate: case report and review of the literature

Fig. 2

a–f Histopathological changes in the small bowel showing various stages of intestinal injury. a, b There is disruption of the mucosal architecture (necrotic/degenerated materials on the mucosal side, loss of villus tip architecture, edema/hyperemia of the lamina propria, dilated lymphatics, and thrombus formation (arrow, a, b). c–f The bowel is affected much more severely. There is necrosis of the mucosa and submucosa with intraluminal-degenerated materials on the mucosal side of the bowel wall (arrowhead), coagulative, and hemorrhagic necrosis of the submucosa and muscle layers (d, arrow), associated with mixed inflammatory cell infiltrate including neutrophils, lymphocytes, and histiocytes (e, f arrow) and vascular thrombosis (e, arrowhead) and muscle layers (d, arrow), associated with mixed inflammatory cell infiltrate including neutrophils, lymphocytes and histiocytes (e, f, arrow), and vascular thrombosis (e, arrowhead)

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